Glucosamine sulphate slows the disease progression of knee osteoarthritis. Osteoarthritis is a major cause of disability and is one of the most numerous types of musculoskeletal disorders.
This disease causes considerable pain and joint immobility. Dr Jean Yves Reginster and colleagues, recruited 212 patients from the outpatient clinic of the Bone and Cartilage Metabolism Research Unit of the University Hospital Centre in Liege, Belgium.The patients were an average age of 50 years and had primary knee osteoarthritis.
They were randomly allocated into 2 groups of 106 patients and took either glucosamine sulphate (1500mg/daily, 1 tablet) or a placebo for a period of 3 years. Joint-space was assessed by digital image analysis.The researchers observed that there was no significant joint-space loss or narrowing of the knee cartilage in the 106 patients taking glucosamine sulphate. Consequently, the patient's pain and stiffness decreased, while function and mobility increased.
References
Reginster, JY et al. Long-term effects of glucosamine sulphate on osteoarthritis progression : a randomised, placebo-controlled clinical trial.
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